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Source: Journal of Thoracic Disease
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Total 8153 results found since Jan 2013.
Primary clear cell adenocarcinoma of the lung: a national analysis
CONCLUSIONS: In this national analysis, we found that the clinicopathological characteristics of CCAL are distinct from those of lung adenocarcinoma, but CCAL is not itself an independent predictor of survival after multivariable adjustment or propensity score-matched analysis.PMID:37691684 | PMC:PMC10482654 | DOI:10.21037/jtd-23-76
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Arian Mansur Zain Saleem Alexandra L Potter Camille Mathey-Andrews Priyanka Senthil Chi-Fu Jeffrey Yang Source Type: research
Long-term survival in esophagectomy for early-stage esophageal cancer versus endoscopic resection plus additional chemoradiotherapy: a systematic review and meta-analysis
CONCLUSIONS: The 2 groups showed no significant results in OS. Although we found that CRT may be suitable for patients with high-risk of relapse or unable to tolerate surgery, it cannot totally replace surgical treatment; further randomized trials are required to verify this view.PMID:37691683 | PMC:PMC10482624 | DOI:10.21037/jtd-23-376
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Yong Chen Yong-Yong Wang Lei Dai Ming-Wu Chen Source Type: research
Primary clear cell adenocarcinoma of the lung: a national analysis
CONCLUSIONS: In this national analysis, we found that the clinicopathological characteristics of CCAL are distinct from those of lung adenocarcinoma, but CCAL is not itself an independent predictor of survival after multivariable adjustment or propensity score-matched analysis.PMID:37691684 | PMC:PMC10482654 | DOI:10.21037/jtd-23-76
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Arian Mansur Zain Saleem Alexandra L Potter Camille Mathey-Andrews Priyanka Senthil Chi-Fu Jeffrey Yang Source Type: research
Long-term survival in esophagectomy for early-stage esophageal cancer versus endoscopic resection plus additional chemoradiotherapy: a systematic review and meta-analysis
CONCLUSIONS: The 2 groups showed no significant results in OS. Although we found that CRT may be suitable for patients with high-risk of relapse or unable to tolerate surgery, it cannot totally replace surgical treatment; further randomized trials are required to verify this view.PMID:37691683 | PMC:PMC10482624 | DOI:10.21037/jtd-23-376
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Yong Chen Yong-Yong Wang Lei Dai Ming-Wu Chen Source Type: research
Systematic review and meta-analysis of segmentectomy < em > vs < /em > . lobectomy for stage IA non-small cell lung cancer
CONCLUSIONS: When a patient is in stage IA and the tumor size is less than 2 cm, segmentectomy should be performed. If the tumor size is between 2 and 3 cm, lobectomy is recommended.PMID:37691674 | PMC:PMC10482631 | DOI:10.21037/jtd-23-410
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Zhangyi Dai Jiawen Hu Cheng Shen Xingqi Mi Qiang Pu Source Type: research
Selection of key genes for dilated cardiomyopathy based on machine learning algorithms and assessment of diagnostic accuracy
CONCLUSIONS: CCL5 and CTGF are key disease-causing genes in dilated cardiomyopathy and have good diagnostic efficiency for the disease. CCL5 and CTGF may be related to immune cell enrichment and myocardial fibrosis, respectively.PMID:37691671 | PMC:PMC10482651 | DOI:10.21037/jtd-23-1086
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Tingting Chen Xiulin Xuan Jiajia Ni Shuyin Jiang Source Type: research
Narrative review: respiratory tract microbiome and never smoking lung cancer
CONCLUSIONS: These findings suggest potential carcinogenic processes such as increased inflammation associated with changes in flora. Additionally, studies showed that increase in certain taxa such as Bacteroides and Spirochetes might have a protective effect on lung cancer risk. The review also provides insight into how understanding the microbial changes can be beneficial for lung cancer treatment and disease-free survival. Larger studies in different populations need to be performed to strengthen the current associations between microbial diversity and lung cancer risk.PMID:37691669 | PMC:PMC10482636 | DOI:10.21037/jtd-22-885
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Sydney Pindling Madelyn Klugman Qing Lan H Dean Hosgood Source Type: research
High level of C-reactive protein as a predictive factor for immune-related adverse events of immune checkpoint inhibitors in non-small cell lung cancer: a retrospective study
CONCLUSIONS: The results suggest that higher level of pretreatment CRP is involved in the development of irAE and poor prognosis. Identification of patients at high risk of irAEs would be of great help. Future multicenter prospective studies are needed to expand on this study.PMID:37691668 | PMC:PMC10482655 | DOI:10.21037/jtd-23-85
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Ren Onodera Shinji Chiba Satoru Nihei Itaru Fujimura Masachika Akiyama Yu Utsumi Hiromi Nagashima Kenzo Kudo Makoto Maemondo Source Type: research
The interplay of physical and cognitive function in rehabilitation of interstitial lung disease patients: a narrative review
CONCLUSIONS: Numerous underlying etiologies of ILD contribute to frailty, skeletal muscle and cognitive function, but their respective neurobiologic mechanisms require further investigation. Exercise training increases physical measures, but complementary approaches may improve their applicability to improve daily activities.PMID:37691666 | PMC:PMC10482628 | DOI:10.21037/jtd-23-209
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Masatoshi Hanada Takako Tanaka Ryo Kozu Yuji Ishimatsu Noriho Sakamoto Ani Orchanian-Cheff Dmitry Rozenberg W Darlene Reid Source Type: research
Dynamic changes in macrophage subtypes during lung cancer progression and metastasis at single-cell resolution
CONCLUSIONS: Our results revealed detailed changes in Macs at different stages of lung cancer progression and metastasis and provided potential therapeutic targets that could be used in future lung cancer treatments.PMID:37691661 | PMC:PMC10482613 | DOI:10.21037/jtd-23-1012
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Jian Wang Weiqing Wu Jinquan Xia Lipeng Chen Dongcheng Liu Guangsuo Wang Lingwei Wang Qijun Zheng Source Type: research
Evaluation of automated sample preparation system for lymph node sampling
CONCLUSIONS: Study results suggest that slides prepared by the automated system are of adequate quality for adequacy assessment with diagnostic concordance when compared to SOC slides.PMID:37691660 | PMC:PMC10482632 | DOI:10.21037/jtd-23-81
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Jennifer D Duke Charles D Sturgis Christopher Hartley Morgan Bailey Michal Reid Ryan Kern Alex Bluestone Hariharan Subramanian Janani Reisenauer Source Type: research
Efficacy and safety of immune checkpoint inhibitors in lung large-cell neuroendocrine carcinoma
CONCLUSIONS: ICIs treatment showed efficacy and safety in advanced L-LCNEC, with the potential for greater benefits in the combined LCNEC subtype.PMID:37691658 | PMC:PMC10482626 | DOI:10.21037/jtd-23-348
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Zheng Shi Jingwen Wei Manyi Xu Zhengbo Song Source Type: research
Recommended first-line management of asymptomatic brain metastases from EGFR mutant and ALK positive non-small cell lung cancer varies significantly according to specialty: an international survey of clinical practice
CONCLUSIONS: Recommendations for the management of BrM from EGFRm or ALK+ NSCLC vary significantly according to oncology sub-specialties. Development of multidisciplinary guidelines and further research on establishing optimal treatment strategies is warranted.PMID:37691657 | PMC:PMC10482634 | DOI:10.21037/jtd-22-697
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Chin Heng Fong Nicholas Meti Timothy Kruser Jessica Weiss Zhihui Amy Liu Hirokazu Takami Yoshitaka Narita Fabio Ynoe de Moraes Archya Dasgupta Choo Khoon Ong James C H Yang Jih Hsiang Lee Natalya Kosyak Nicholas Pavlakis Paul Kongkham Mark Doherty Natasha Source Type: research
4-phenylbutyric acid re-trafficking hERG/G572R channel protein by modulating the endoplasmic reticulum stress-associated chaperones and endoplasmic reticulum-associated degradation gene
CONCLUSIONS: 4-PBA corrects hERG channel transport defects by inhibiting excessive ERS and the endoplasmic reticulum-associated degradation (ERAD)-related gene E3 ubiquitin ligase HRD1. Additionally, 4-PBA improved WT/G572R channel current. 4-PBA is expected to be developed as a new treatment method for LQT2.PMID:37691654 | PMC:PMC10482650 | DOI:10.21037/jtd-23-1252
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Wen Tang Dihui Cai Yin Fu Zequn Zheng Xiaoyan Huang Rami N Khouzam Yongfei Song Jiangfang Lian Source Type: research
< em > K. pneumoniae < /em > and < em > M. smegmatis < /em > infect epithelial cells via different strategies
CONCLUSIONS: Our results emphasized the immunoprotection and immunomodulation of lung epithelial cells against exogenous pathogenic microorganisms, indicating that different pathogens damaged the host through different strategies and induced varying innate immune responses. At the same time, they provided important clues and key immune factors for dealing with complicated pulmonary infections.PMID:37691650 | PMC:PMC10482649 | DOI:10.21037/jtd-23-493
Source: Journal of Thoracic Disease - September 11, 2023 Category: Respiratory Medicine Authors: Renjing Hu Lin Wan Xiaoyun Liu Jie Lu Xichi Hu Xiaoli Zhang Min Zhang Source Type: research
